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Vera SantosVera Santos

The FDA Is Right to Demand a Sham Trial for Huntington's Gene Therapy

Crash DavisCrash Davis

The FDA Wants Huntington's Patients to Wait 5 Years for a Placebo Brain Surgery

Health

Vitamin D Won't Save You From COVID, But the Long COVID Signal Is Worth Watching

A 1,747-person randomized trial just killed the case for vitamin D against acute COVID. The long COVID signal in the same data is borderline and unconfirmed. The depression evidence is actually interesting. These are three different conclusions, and the wellness industry will treat them as one.

By Dr. Alex Chen · 3 min read

Science

AMT-130 Cannot Buy Its Way to a Breakthrough

An anonymous FDA official called AMT-130 a failure. uniQure calls it a disease-modifying breakthrough. The disagreement is not philosophical; it is a direct clash over what Phase 1/2 biomarker data can and cannot tell us. One side is right.

By Dr. Nadia Osei · 3 min read